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The benefits of Niacinamide

Monday, 25. February 2019

Niacinamide is a multifunctional active whose efficacy has been substantiated in numerous scientific journals and publications.

Improves skin barrier function

Niacinamide increases barrier layer proteins like Involucrin and Filaggrin which are critical in the formation of natural moisturizing factors.

“Bissett DL (2002) Topical niacinamide and barrier enhancement. Cutis 70S:8-12.”

Niacinamide increases ceramide and free fatty acid levels in stratum corneum which improves epidermal permeability barrier.

“Tanno O, Ota Y, Kitamura N, et al. Nicotinamide increases biosynthesis of Ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143:524-531.”

Anti-Aging

5% topical Niacinamide reduces yellowing, wrinkling, red blotchiness, and hyper-pigmented spots in aging facial skin.

“Bissett DL, et. al. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. (2004).”

Anti-Acne

5% Nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris. No side effect was observed during the treatment.

“J Res Med Sci. 2013 Feb; 18(2): 115–117. Comparison of topical 5% nicotinamid gel versus 2% clindamycin gel in the treatment of the mild-moderate acne vulgaris: A double-blinded randomized clinical trial, Zabiolah Shahmoradi, Farib Iraji, Amir Hossein Siadat, and Azamosadat Ghorbaini.”

Protects skin against UV induced immunosuppression

Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans. Longwave UVA is highly immune suppressive even at doses equivalent to 20 min of sun exposure. Niacinamide protected skin against both UVB and UVA induced immunosuppression and is a promising agent for skin cancer prevention.

“Sivapirabu G, Yiasemides E, Halliday GM, Park J, Damian DL, Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans. Br J Dermatol. 2009 Dec;161(6):1357-64.”


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